Role of PBMCs in advancements of HCV induced disease progression of liver
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Abstract
HCV is a life-threatening disease that causes several liver disorders such as liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC)-second leading type of cancer. Although directing acting antivirals (DAAs) are showing some promising results, despite the liver complications caused by HCV are likely to persist in near future. HCV induced HCC is a slowly progressing multiple step process. This carcinogenesis is acquired over the years via production of a cirrhotic tissue microenvironment. Some cellular proteins and eukaryotic translation initiators were seen to increase translation of HCV polyprotein precursor and hence intracellular replication of viral gene. Which in turn upsets the regulation of several cytokines leading to cytokine storm in the liver and peripheral blood mononuclear cells (PBMCs). This plays a role in liver disease progression, thus signifying role of PBMCs in HCC induction over time.
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Pakistan Journal Emerging Science and Technologies (PJEST) in collaboration with Govt. Islamia Graduate College Civil Lines Lahore, Pakistan is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
References
Y.-C. Kwon, R. B. Ray, and R. Ray, "Hepatitis C virus infection: establishment of chronicity and liver disease progression," EXCLI journal, vol. 13, p. 977, 2014.
A. Khan, A. M. Tareen, A. Ikram, H. Rahman, A. Wadood, M. Qasim, et al., "Prevalence of HCV among the young male blood donors of Quetta region of Balochistan, Pakistan," Virology journal, vol. 10, pp. 1-4, 2013.
S. Park, E. Lee, C. Rim, and J. Seong, "Cell-free DNA as a predictive marker after radiation therapy for hepatocellular carcinoma," International Journal of Radiation Oncology, Biology, Physics, vol. 99, pp. S89-S90, 2017.
L. Cao, B. Yu, D. Kong, Q. Cong, T. Yu, Z. Chen, et al., "Functional expression and characterization of the envelope glycoprotein E1E2 heterodimer of hepatitis C virus," PLoS pathogens, vol. 15, p. e1007759, 2019.
L. Shekhtman, M. Navasa, N. Sansone, G. Crespo, G. Subramanya, T. L. Chung, et al., "Modeling hepatitis C virus kinetics during liver transplantation reveals the role of the liver in virus clearance," Elife, vol. 10, p. e65297, 2021.
N. I. o. Health, "Proceedings of the National Institutes of Health Consensus Development Conference Statement-Management of Hepatitis C, 10-12 June 2002," Hepatology, vol. 36, pp. S3-S20, 2002.
C. S. García-Romero, C. Guzman, A. Cervantes, and M. Cerbón, "Liver disease in pregnancy: Medical aspects and their implications for mother and child," Annals of hepatology, vol. 18, pp. 553-562, 2019.
S. Niknamian, "MicroRNAs biomarkers profiling in diagnosis and therapeutic management of hepatitis B virus infection," Aditum Journal of Clinical and Biomedical Research, vol. 2, 2021.
M. A. Khattab, Y. Zakaria, E. Sadek, A. E. Fatah, S. Aliaa, M. Fouad, et al., "Detection of hepatitis C virus (HCV) RNA in the peripheral blood mononuclear cells of HCV-infected patients following sustained virologic response," Clinical and Experimental Medicine, pp. 1-10, 2022.
F. Bohne, M. Martínez-Llordella, J.-J. Lozano, R. Miquel, C. Benítez, M.-C. Londoño, et al., "Intra-graft expression of genes involved in iron homeostasis predicts the development of operational tolerance in human liver transplantation," The Journal of clinical investigation, vol. 122, pp. 368-382, 2012.
G. M. Lauer and B. D. Walker, "Hepatitis C virus infection," New England journal of medicine, vol. 345, pp. 41-52, 2001.
I. Abbadi, M. Lkhider, B. Kitab, K. Jabboua, I. Zaidane, A. Haddaji, et al., "Non-primate hepacivirus transmission and prevalence: Novel findings of virus circulation in horses and dogs in Morocco," Infection, Genetics and Evolution, vol. 93, p. 104975, 2021.
D. Moskophidis, F. Lechner, H. Pircher, and R. M. Zinkernagel, "Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells," Nature, vol. 362, pp. 758-761, 1993.
A. M. Grabowska, F. Lechner, P. Klenerman, P. J. Tighe, S. Ryder, J. K. Ball, et al., "Direct ex vivo comparison of the breadth and specificity of the T cells in the liver and peripheral blood of patients with chronic HCV infection," European journal of immunology, vol. 31, pp. 2388-2394, 2001.
P. Simmonds, J. Bukh, C. Combet, G. Deléage, N. Enomoto, S. Feinstone, et al., "Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypes," Hepatology, vol. 42, pp. 962-973, 2005.
C. G. Yergin, "Immunoregulation By HCV-generated Myeloid-Derived Suppressor Cells," University of Virginia, 2016.
T. Von Hahn, J. C. Yoon, H. Alter, C. M. Rice, B. Rehermann, P. Balfe, et al., "Hepatitis C virus continuously escapes from neutralizing antibody and T-cell responses during chronic infection in vivo," Gastroenterology, vol. 132, pp. 667-678, 2007.
I. Castillo, M. Pardo, J. Bartolomé, N. Ortiz-Movilla, E. Rodríguez-Iñigo, S. d. Lucas, et al., "Occult hepatitis C virus infection in patients in whom the etiology of persistently abnormal results of liver-function tests is unknown," The Journal of infectious diseases, vol. 189, pp. 7-14, 2004.
J. T. Stapleton, W. N. Schmidt, and L. Katz, "Seronegative hepatitis C virus infection, not just RNA detection," vol. 190, ed: The University Chicago Press, 2004, pp. 651-652.
N. L. Benali-Furet, M. Chami, L. Houel, F. De Giorgi, F. Vernejoul, D. Lagorce, et al., "Hepatitis C virus core triggers apoptosis in liver cells by inducing ER stress and ER calcium depletion," Oncogene, vol. 24, pp. 4921-4933, 2005.
M. Pardo, J. López‐Alcorocho, E. Rodríguez‐Iñigo, I. Castillo, and V. Carreno, "Comparative study between occult hepatitis C virus infection and chronic hepatitis C," Journal of viral hepatitis, vol. 14, pp. 36-40, 2007.
C. E. DeSantis, C. C. Lin, A. B. Mariotto, R. L. Siegel, K. D. Stein, J. L. Kramer, et al., "Cancer treatment and survivorship statistics, 2014," CA: a cancer journal for clinicians, vol. 64, pp. 252-271, 2014.
F. Kanwal, H. B. El-Serag, and D. Ross, "Surveillance for hepatocellular carcinoma: can we focus on the mission?," Clinical Gastroenterology and Hepatology, vol. 13, pp. 805-807, 2015.
R. J. Wong, R. Cheung, and A. Ahmed, "Nonalcoholic steatohepatitis is the most rapidly growing indication for liver transplantation in patients with hepatocellular carcinoma in the US," Hepatology, vol. 59, pp. 2188-2195, 2014.
I. M. Jacobson, G. L. Davis, H. El–Serag, F. Negro, and C. Trépo, "Prevalence and challenges of liver diseases in patients with chronic hepatitis C virus infection," Clinical Gastroenterology and Hepatology, vol. 8, pp. 924-933, 2010.
J. W. Galbraith, J. P. Donnelly, R. A. Franco, E. T. Overton, J. B. Rodgers, and H. E. Wang, "National estimates of healthcare utilization by individuals with hepatitis C virus infection in the United States," Clinical infectious diseases, vol. 59, pp. 755-764, 2014.
V. Yakovchenko, R. E. Bolton, M.-L. Drainoni, and A. L. Gifford, "Primary care provider perceptions and experiences of implementing hepatitis C virus birth cohort testing: a qualitative formative evaluation," BMC health services research, vol. 19, pp. 1-8, 2019.
R. Nawaz, S. Zahid, M. Idrees, S. Rafique, M. Shahid, A. Ahad, et al., "HCV-induced regulatory alterations of IL-1β, IL-6, TNF-α, and IFN-ϒ operative, leading liver en-route to non-alcoholic steatohepatitis," Inflammation Research, vol. 66, pp. 477-486, 2017.
E. Caparrós and R. Francés, "The interleukin-20 cytokine family in liver disease," Frontiers in Immunology, vol. 9, p. 1155, 2018.
S. Radaeva, R. Sun, H. n. Pan, F. Hong, and B. Gao, "Interleukin 22 (IL‐22) plays a protective role in T cell‐mediated murine hepatitis: IL‐22 is a survival factor for hepatocytes via STAT3 activation," Hepatology, vol. 39, pp. 1332-1342, 2004.
L. Yang, Y. Zhang, L. Wang, F. Fan, L. Zhu, Z. Li, et al., "Amelioration of high fat diet induced liver lipogenesis and hepatic steatosis by interleukin-22," Journal of hepatology, vol. 53, pp. 339-347, 2010.
K. Wolk, H. S. Haugen, W. Xu, E. Witte, K. Waggie, M. Anderson, et al., "IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-γ are not," Journal of molecular medicine, vol. 87, pp. 523-536, 2009.
S. Meller, J. Di Domizio, K. S. Voo, H. C. Friedrich, G. Chamilos, D. Ganguly, et al., "TH 17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26," Nature immunology, vol. 16, pp. 970-979, 2015.
E. Stephen-Victor, H. Fickenscher, and J. Bayry, "IL-26: an emerging proinflammatory member of the IL-10 cytokine family with multifaceted actions in antiviral, antimicrobial, and autoimmune responses," PLoS pathogens, vol. 12, p. e1005624, 2016.
K. Ohnuma, R. Hatano, T. M. Aune, H. Otsuka, S. Iwata, N. H. Dang, et al., "Regulation of pulmonary graft-versus-host disease by IL-26+ CD26+ CD4 T lymphocytes," The Journal of Immunology, vol. 194, pp. 3697-3712, 2015.
M. E. Menezes, S. Bhatia, P. Bhoopathi, S. K. Das, L. Emdad, S. Dasgupta, et al., "MDA-7/IL-24: multifunctional cancer killing cytokine," Anticancer Genes, pp. 127-153, 2014.
A. Wieckowska, B. G. Papouchado, Z. Li, R. Lopez, N. N. Zein, and A. E. Feldstein, "Increased hepatic and circulating interleukin-6 levels in human nonalcoholic steatohepatitis," Official journal of the American College of Gastroenterology| ACG, vol. 103, pp. 1372-1379, 2008.
H. Tilg and A. M. Diehl, "Cytokines in alcoholic and nonalcoholic steatohepatitis," New England Journal of Medicine, vol. 343, pp. 1467-1476, 2000.
R. C. Lee, R. L. Feinbaum, and V. Ambros, "The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14," cell, vol. 75, pp. 843-854, 1993.
V. Ambros, "The functions of animal microRNAs," Nature, vol. 431, pp. 350-355, 2004.
S. Cermelli, A. Ruggieri, J. A. Marrero, G. N. Ioannou, and L. Beretta, "Circulating microRNAs in patients with chronic hepatitis C and non-alcoholic fatty liver disease," PloS one, vol. 6, p. e23937, 2011.
H. Yamada, K. Suzuki, N. Ichino, Y. Ando, A. Sawada, K. Osakabe, et al., "Associations between circulating microRNAs (miR-21, miR-34a, miR-122 and miR-451) and non-alcoholic fatty liver," Clinica chimica acta, vol. 424, pp. 99-103, 2013.
S. Bala and G. Szabo, "MicroRNA signature in alcoholic liver disease," International journal of hepatology, vol. 2012, 2012.
D. Blaya, M. Coll, D. Rodrigo-Torres, M. Vila-Casadesús, J. Altamirano, M. Llopis, et al., "Integrative microRNA profiling in alcoholic hepatitis reveals a role for microRNA-182 in liver injury and inflammation," Gut, vol. 65, pp. 1535-1545, 2016.
F. Borel, P. Konstantinova, and P. L. Jansen, "Diagnostic and therapeutic potential of miRNA signatures in patients with hepatocellular carcinoma," Journal of hepatology, vol. 56, pp. 1371-1383, 2012.
Y. Q. Cheng, J. P. Ren, J. Zhao, J. M. Wang, Y. Zhou, G. Y. Li, et al., "Micro RNA‐155 regulates interferon‐γ production in natural killer cells via T im‐3 signalling in chronic hepatitis C virus infection," Immunology, vol. 145, pp. 485-497, 2015.
O. Cheung, P. Puri, C. Eicken, M. J. Contos, F. Mirshahi, J. W. Maher, et al., "Nonalcoholic steatohepatitis is associated with altered hepatic MicroRNA expression," Hepatology, vol. 48, pp. 1810-1820, 2008.
S. Bala, M. Marcos, K. Kodys, T. Csak, D. Catalano, P. Mandrekar, et al., "Up-regulation of microRNA-155 in macrophages contributes to increased tumor necrosis factor α (TNFα) production via increased mRNA half-life in alcoholic liver disease," Journal of Biological Chemistry, vol. 286, pp. 1436-1444, 2011.
M. Lagos-Quintana, R. Rauhut, A. Yalcin, J. Meyer, W. Lendeckel, and T. Tuschl, "Identification of tissue-specific microRNAs from mouse," Current biology, vol. 12, pp. 735-739, 2002.
M. Girard, E. Jacquemin, A. Munnich, S. Lyonnet, and A. Henrion-Caude, "miR-122, a paradigm for the role of microRNAs in the liver," Journal of hepatology, vol. 48, pp. 648-656, 2008.
W. Hou, Q. Tian, J. Zheng, and H. L. Bonkovsky, "MicroRNA‐196 represses Bach1 protein and hepatitis C virus gene expression in human hepatoma cells expressing hepatitis C viral proteins," Hepatology, vol. 51, pp. 1494-1504, 2010.
P. J. Starkey Lewis, J. Dear, V. Platt, K. J. Simpson, D. G. Craig, D. J. Antoine, et al., "Circulating microRNAs as potential markers of human drug‐induced liver injury," Hepatology, vol. 54, pp. 1767-1776, 2011.
A. J. van der Meer, B. J. Veldt, J. J. Feld, H. Wedemeyer, J.-F. Dufour, F. Lammert, et al., "Association between sustained virological response and all-cause mortality among patients with chronic hepatitis C and advanced hepatic fibrosis," Jama, vol. 308, pp. 2584-2593, 2012.
B. Clarke, "Molecular virology of hepatitis C virus," Journal of General Virology, vol. 78, pp. 2397-2410, 1997.
A. Manzin, M. Candela, S. Paolucci, M. Caniglia, A. Gabrielli, and M. Clementi, "Presence of hepatitis C virus (HCV) genomic RNA and viral replicative intermediates in bone marrow and peripheral blood mononuclear cells from HCV-infected patients," Clinical and diagnostic laboratory immunology, vol. 1, p. 160, 1994.
J.-T. Wang, J.-C. Sheu, J.-T. Lin, T.-H. Wang, and D. S. Chen, "Detection of replicative form of hepatitis C virus RNA in peripheral blood mononuclear cells," Journal of Infectious Diseases, vol. 166, pp. 1167-1169, 1992.
M. G. Saleh, C. J. Tibbs, J. Koskinas, L. M. Pereira, A. B. Bomford, B. C. Portmann, et al., "Hepatic and extrahepatic hepatitis C virus replication in relation to response to interferon therapy," Hepatology, vol. 20, pp. 1399-1404, 1994.
T. Chang, K. Young, Y. Yang, H. Lei, and H. Wu, "Hepatitis C virus RNA in peripheral blood mononuclear cells: comparing acute and chronic hepatitis C virus infection," Hepatology, vol. 23, pp. 977-981, 1996.
Y. K. Shimizu, A. Iwamoto, M. Hijikata, R. H. Purcell, and H. Yoshikura, "Evidence for in vitro replication of hepatitis C virus genome in a human T-cell line," Proceedings of the National Academy of Sciences, vol. 89, pp. 5477-5481, 1992.
Y. K. Shimizu, H. Igarashi, T. Kiyohara, M. Shapiro, D. C. Wong, R. H. Purcell, et al., "Infection of a chimpanzee with hepatitis C virus grown in cell culture," Journal of General Virology, vol. 79, pp. 1383-1386, 1998.
C. Feray, D. Samuel, V. Thiers, M. Gigou, F. Pichon, A. Bismuth, et al., "Reinfection of liver graft by hepatitis C virus after liver transplantation," The Journal of clinical investigation, vol. 89, pp. 1361-1365, 1992.
T. Laskus, M. Radkowski, J. Wilkinson, H. Vargas, and J. Rakela, "The origin of hepatitis C virus reinfecting transplanted livers: serum-derived versus peripheral blood mononuclear cell-derived virus," The Journal of infectious diseases, vol. 185, pp. 417-421, 2002.
I. Castillo, E. Rodriguez-Inigo, J. Bartolome, S. De Lucas, N. Ortiz-Movilla, J. López-Alcorocho, et al., "Hepatitis C virus replicates in peripheral blood mononuclear cells of patients with occult hepatitis C virus infection," Gut, vol. 54, pp. 682-685, 2005.
G.-Z. Gong, L.-Y. Lai, Y.-F. Jiang, Y. He, and X.-S. Su, "HCV replication in PBMC and its influence on interferon therapy," World Journal of Gastroenterology: WJG, vol. 9, p. 291, 2003.
F. A. Di Lello, A. C. A. Culasso, C. Parodi, P. Baré, R. H. Campos, and G. García, "New evidence of replication of hepatitis C virus in short-term peripheral blood mononuclear cell cultures," Virus research, vol. 191, pp. 1-9, 2014.
P. Baré, "Hepatitis C virus and peripheral blood mononuclear cell reservoirs Patricia Baré," World journal of hepatology, vol. 1, p. 67, 2009.
A. Alhetheel, A. Albarrag, A. Hakami, Z. Shakoor, K. Alswat, A. Abdo, et al., "In the peripheral blood mononuclear cells (PBMCs) of HCV infected patients the expression of STAT1 and IRF-1 is downregulated while that of caspase-3 upregulated," Acta virologica, vol. 64, pp. 352-358, 2020.
L. Deng, T. Adachi, K. Kitayama, Y. Bungyoku, S. Kitazawa, S. Ishido, et al., "Hepatitis C virus infection induces apoptosis through a Bax-triggered, mitochondrion-mediated, caspase 3-dependent pathway," Journal of virology, vol. 82, pp. 10375-10385, 2008.
T. Marcello, A. Grakoui, G. Barba–Spaeth, E. S. Machlin, S. V. Kotenko, M. R. Macdonald, et al., "Interferons α and λ inhibit hepatitis C virus replication with distinct signal transduction and gene regulation kinetics," Gastroenterology, vol. 131, pp. 1887-1898, 2006.
S. V. Kotenko, G. Gallagher, V. V. Baurin, A. Lewis-Antes, M. Shen, N. K. Shah, et al., "IFN-λs mediate antiviral protection through a distinct class II cytokine receptor complex," Nature immunology, vol. 4, pp. 69-77, 2003.
S. Cooper, A. L. Erickson, E. J. Adams, J. Kansopon, A. J. Weiner, D. Y. Chien, et al., "Analysis of a successful immune response against hepatitis C virus," Immunity, vol. 10, pp. 439-449, 1999.
O. Waidmann, V. Bihrer, T. Pleli, H. Farnik, A. Berger, S. Zeuzem, et al., "Serum microRNA‐122 levels in different groups of patients with chronic hepatitis B virus infection," Journal of viral hepatitis, vol. 19, pp. e58-e65, 2012.
S. J. Weston, R. L. Leistikow, K. R. Reddy, M. Torres, A. M. Wertheimer, D. M. Lewinsohn, et al., "Reconstitution of hepatitis C virus–specific T‐cell–mediated immunity after liver transplantation," Hepatology, vol. 41, pp. 72-81, 2005.